CHD2

Across TCGA patient cohorts, CHD2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD2-associated genes across cancer lineages are FoxM1, Annexin-1, and TFRC. Each is linked with CHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHD2-to-partner and partner-to-CHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CHD2-low versus CHD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD2→partner) and Y-score (partner→CHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.151	+1.180	.024	.005	3	2
UCEC	Annexin-1 →	+0.564	+1.469	<.001	<.001	3	2
UCEC	TFRC →	+0.468	+2.392	<.001	<.001	3	2
UCEC	ATM →	-0.494	-1.861	<.001	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.119	+3.467	.001	.002	3	2
COAD	Chk2_pT68 →	-0.162	-2.296	.029	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

FoxM1 by CHD2 expression — UCEC

Explore this box plot interactively →