CHD2

Across TCGA cell cohorts, CHD2 mutation is significantly associated with the RNA expression of many other genes, with 1,188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD2-associated genes across cancer lineages are SENP6, TTK, and GTF2H2. Each is linked with CHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHD2-to-partner and partner-to-CHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP6 grouped by CHD2-low versus CHD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD2→partner) and Y-score (partner→CHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SENP6 →	+0.661	+2.265	<.001	.001	3	2
LARGE_INTESTINE	TTK →	+0.520	+2.265	.002	.001	3	2
LARGE_INTESTINE	GTF2H2 →	+0.824	+2.265	.004	.001	3	2
LARGE_INTESTINE	LRIT3 →	+0.146	+2.573	.006	.005	3	2
LARGE_INTESTINE	RPF2 →	+0.631	+2.265	<.001	.001	3	2
LUNG_NSCLC_LUAD	EXOC1L →	+0.167	+3.544	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,188 associations by consensus.

SENP6 by CHD2 expression — LARGE_INTESTINE

Explore this box plot interactively →