CHCHD7

Across TCGA pan-cancer cohorts, CHCHD7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CHCHD7 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CHCHD7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHCHD7 expression acts as an unfavorable survival marker, although some lineages such as MESO and CHOL show a favorable association.

UVM, UCEC, and LGG are the cancer types where CHCHD7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.167	0.793	<.001	87	view →
UCEC	DFS	Median	All	0.545	0.743	<.001	50	view →
LGG	DFS	Median	All	0.783	0.879	<.001	36	view →
MESO	DFS	Tertile	II,III,IV	0.574	0.324	.008	33	view →
ACC	DFS	Quartile	IV	0.047	0.453	.006	29	view →
KIRP	OS	Quartile	III,IV	0.108	0.707	.004	29	view →
CHOL	OS	Tertile	All	1.000	0.515	.011	26	view →
LUAD	DFS	Tertile	IV	0.788	0.361	.009	25	view →
DLBC	DFS	Tertile	All	0.984	0.558	.002	25	view →
KIRC	DFS	Tertile	All	0.748	0.613	.011	22	view →
STAD	DFS	Tertile	III,IV	0.444	0.760	.006	21	view →
BLCA	DFS	Quartile	IV	0.355	0.541	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CHCHD7–UVM (DFS)

Open the UVM breakdown →