CHCHD6

Across TCGA patient cohorts, CHCHD6 protein abundance is significantly associated with the RNA expression of many other genes, with 9,978 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHCHD6-associated genes across cancer lineages are MAPRE3, SPR, and CCDC150. Each is linked with CHCHD6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHCHD6-to-partner and partner-to-CHCHD6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHCHD6 versus MAPRE3 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD6→partner) and Y-score (partner→CHCHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAPRE3 →	+0.773	+0.488	<.001	<.001	3	5
LSCC	SPR →	+0.910	+0.456	<.001	<.001	3	4
OV	CCDC150 →	-0.738	-0.406	<.001	.004	3	4
BRCA	BUB1B →	-0.690	-0.330	.003	.004	3	4
LSCC	CEP63 →	+0.413	+0.455	.001	<.001	3	4
OV	WDR5B →	+0.646	+0.547	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,978 associations by consensus.

CHCHD6 vs MAPRE3 — LSCC

Explore this scatter interactively →