CHCHD6

Across TCGA patient cohorts, CHCHD6 mutation is significantly associated with the RNA expression of many other genes, with 462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHCHD6-associated genes across cancer lineages are MTCYBP12, RPSAP24, and RAD17. Each is linked with CHCHD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHCHD6-to-partner and partner-to-CHCHD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP12 grouped by CHCHD6-low versus CHCHD6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD6→partner) and Y-score (partner→CHCHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCYBP12 →	+0.078	+5.044	<.001	.009	3	3
UCEC	RPSAP24 →	+0.120	+2.371	.002	.005	3	2
UCEC	RAD17 →	+0.512	+3.227	.009	.009	3	1
UCEC	MGAT4B →	+0.625	+3.480	.001	.002	3	1
UCEC	C1orf50 →	+0.486	+3.502	<.001	.002	3	1
UCEC	NDUFAF2 →	+0.729	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 462 associations by consensus.

MTCYBP12 by CHCHD6 expression — LUAD

Explore this box plot interactively →