CHCHD6

Across TCGA patient cohorts, CHCHD6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHCHD6-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK2, and PRAS40_pT246. Each is linked with CHCHD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD6-to-partner and partner-to-CHCHD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by CHCHD6-low versus CHCHD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD6→partner) and Y-score (partner→CHCHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.534	+3.009	.022	.019	3	1
UCEC	JNK2 →	+0.283	+3.169	.009	.020	3	1
UCEC	PRAS40_pT246 →	+0.232	+3.183	.014	.010	3	1
UCEC	Tuberin_pT1462 →	+0.418	+2.817	<.001	.036	3	1
UCEC	ATM →	-0.582	-3.169	.019	.020	3	1
UCEC	ACVRL1 →	-0.157	-3.169	.036	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK-3a-b_pS21_S9 by CHCHD6 expression — UCEC

Explore this box plot interactively →