CHCHD5

Across TCGA pan-cancer cohorts, CHCHD5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CHCHD5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CHCHD5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHCHD5 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, LUAD, and HNSC are the cancer types where CHCHD5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.837	<.001	12	view →
LUAD	Female	II,III,IV	+0.590	<.001	9	view →
HNSC	Male	All	−0.288	<.001	8	view →
PDAC	Male	All	+0.692	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CHCHD5–CCRCC

Open the CCRCC breakdown →