CHCHD5

Across TCGA cell cohorts, CHCHD5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHCHD5-associated genes across cancer lineages are DAOA, LCE1C, and SLC5A8. Each is linked with CHCHD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD5-to-partner and partner-to-CHCHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAOA grouped by CHCHD5-low versus CHCHD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD5→partner) and Y-score (partner→CHCHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DAOA →	+0.049	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DAOA by CHCHD5 expression — BLOOD_Leukemia

Explore this box plot interactively →