CHCHD2P7

Across TCGA pan-cancer cohorts, CHCHD2P7 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CHCHD2P7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHCHD2P7 RNA is repressed in tumor relative to normal tissue. In most cancer types CHCHD2P7 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where CHCHD2P7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD2P7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.567	<.001	10	view →
HNSC	Male	All	+0.436	<.001	8	view →
LIHC	Male	All	+0.307	<.001	5	view →
KIRP	All	All	−0.374	.003	2	view →
ESCA	All	II,III,IV	+0.170	.029	2	view →
LUAD	All	II,III,IV	−0.169	.012	2	view →
CHOL	All	All	+0.543	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CHCHD2P7–KIRC

Open the KIRC breakdown →