CHCHD10

Across TCGA pan-cancer cohorts, CHCHD10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHCHD10 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHCHD10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHCHD10 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where CHCHD10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.860	1.000	.002	13	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	12	view →
LUAD	OS	Tertile	III,IV	0.819	0.247	.011	12	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.814	.011	8	view →
CCRCC	DFS	Median	III,IV	0.809	1.000	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHCHD10–HNSC (DFS)

Open the HNSC breakdown →