CHCHD10

Across TCGA patient cohorts, CHCHD10 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CHCHD10-associated genes across cancer lineages are CSPG4P3Y, OR6N1, and OR51C1P. Each is linked with CHCHD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD10-to-partner and partner-to-CHCHD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSPG4P3Y grouped by CHCHD10-low versus CHCHD10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD10→partner) and Y-score (partner→CHCHD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CSPG4P3Y →	+0.012	+6.199	<.001	.001	3	1
SKCM	OR6N1 →	+0.080	+4.979	<.001	.009	3	1
SKCM	OR51C1P →	+0.054	+6.328	<.001	.001	3	1
SKCM	SLC29A4P1 →	+0.054	+5.867	<.001	.003	3	1
SKCM	GRPEL2P2 →	+0.070	+5.224	<.001	.007	3	1
SKCM	CHP1P3 →	+0.133	+5.680	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CSPG4P3Y by CHCHD10 expression — SKCM

Explore this box plot interactively →