CHAT

Across TCGA pan-cancer cohorts, CHAT Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CHAT data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CHAT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHAT expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

UVM, LUAD, and SCLC are the cancer types where CHAT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.218	0.718	.006	24	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	6	view →
COAD	OS	Median	III,IV	0.133	0.780	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.956	0.864	.031	4	view →
BLCA	OS	Median	IV	0.193	0.598	.047	3	view →
ESCA	DFS	Median	All	0.220	0.537	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CHAT–UVM (OS)

Open the UVM breakdown →