CHAT

Across TCGA patient cohorts, CHAT protein abundance is significantly associated with the RNA expression of many other genes, with 3,091 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHAT-associated genes across cancer lineages are SLC9A8, ZDHHC15, and MAGOHB. Each is linked with CHAT in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAT-to-partner and partner-to-CHAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHAT versus SLC9A8 in LSCC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAT→partner) and Y-score (partner→CHAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC9A8 →	-0.427	-0.965	.001	.007	3	2
LUAD	ZDHHC15 →	+0.954	+1.351	<.001	<.001	3	1
LUAD	MAGOHB →	-0.412	-1.149	.003	.003	3	1
LUAD	HPCA →	+0.594	+1.158	<.001	<.001	3	1
LUAD	PDE1B →	+0.651	+1.382	.008	.003	3	1
LUAD	FRMD8 →	+0.561	+1.101	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,091 associations by consensus.

CHAT vs SLC9A8 — LSCC

Explore this scatter interactively →