CHAT

Across TCGA cell cohorts, CHAT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,259 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CHAT-associated GO terms across cancer lineages are Positive regulation of cation transmembrane transport, Post-Golgi vesicle-mediated transport, and RNA polymerase I preinitiation complex assembly. Each is linked with CHAT in more than 5 cancer types. Because this analysis shows association rather than direction, both CHAT-to-partner and partner-to-CHAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cation transmembrane transport grouped by CHAT-low versus CHAT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAT→partner) and Y-score (partner→CHAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cation transmembrane transport →	-0.126	-2.181	<.001	<.001	3	6
SKIN	Post-Golgi vesicle-mediated transport →	+0.049	+0.012	<.001	.006	3	5
BONE	RNA polymerase I preinitiation complex assembly →	+0.126	+2.364	<.001	<.001	3	5
BONE	Positive regulation of monoatomic ion transmembrane transport →	-0.116	-1.892	.001	.002	2	6
BONE	Positive regulation of monoatomic ion transport →	-0.125	-1.747	<.001	<.001	3	5
BONE	Nuclear pore organization →	+0.186	+2.295	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,259 associations by consensus.

Positive regulation of cation transmembrane transport by CHAT expression — BONE

Explore this box plot interactively →