CHAT

Across TCGA cell cohorts, CHAT mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHAT-associated genes across cancer lineages are KRTAP4-6, OR4D2, and TGIF2LX. Each is linked with CHAT in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAT-to-partner and partner-to-CHAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-6 grouped by CHAT-low versus CHAT-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAT→partner) and Y-score (partner→CHAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP4-6 →	+0.111	+4.369	<.001	.008	3	2
CNS	OR4D2 →	+0.015	+5.357	<.001	.001	3	2
LUNG_SCLC	TGIF2LX →	+1.960	+3.528	<.001	.006	3	1
LUNG_SCLC	OR1N1 →	+0.107	+3.220	<.001	.002	3	1
LUNG_SCLC	PROP1 →	+0.210	+3.428	<.001	.008	3	1
LUNG_SCLC	C1orf146 →	+0.055	+2.874	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

KRTAP4-6 by CHAT expression — SOFT_TISSUE

Explore this box plot interactively →