Across TCGA pan-cancer cohorts, CHAMP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHAMP1 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHAMP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHAMP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, SKCM, and UCEC are the cancer types where CHAMP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.190	0.668	<.001	25	view →
SKCM	OS	Median	All	0.346	0.784	.009	12	view →
UCEC	DFS	Median	All	0.964	0.626	.017	8	view →
LIHC	DFS	Median	All	0.096	0.543	.028	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CHAMP1 tumor-vs-normal RNA expression · all CHAMP1 data types