Across TCGA patient cohorts, CHAMP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAMP1-associated genes across cancer lineages are Paxillin, P-Cadherin, and PDCD4. Each is linked with CHAMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAMP1-to-partner and partner-to-CHAMP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAMP1→partner) and Y-score (partner→CHAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Paxillin →	+0.178	+1.440	.048	.024	3	2
UCEC	P-Cadherin →	-0.111	-2.459	.026	.018	3	2
UCEC	PDCD4 →	-0.520	-1.736	.001	.007	3	2
UCEC	14-3-3_beta →	-0.084	-2.088	.015	.016	3	1
UCEC	eIF4E →	+0.145	+1.736	.047	.007	3	1
UCEC	A-Raf_pS299 →	-0.089	-1.440	.031	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

CHAMP1 survival (RNA) · tumor vs normal (RNA) · all CHAMP1 data types