Across TCGA cell cohorts, CHAMP1 mutation is significantly associated with the drug of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHAMP1-associated genes across cancer lineages are Cytarabine, Rucaparib, and MK-1775. Each is linked with CHAMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAMP1-to-partner and partner-to-CHAMP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAMP1→partner) and Y-score (partner→CHAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+0.824	+2.655	.034	.044	3	1
LARGE_INTESTINE	Rucaparib →	+0.325	+2.932	.029	.019	3	1
LARGE_INTESTINE	MK-1775 →	+0.309	+2.678	.036	.037	3	1
LARGE_INTESTINE	UNC0642 →	+0.203	+2.658	.030	.043	3	1
LARGE_INTESTINE	Luminespib →	+0.561	+2.807	.042	.037	3	1
LARGE_INTESTINE	GSK2606414 →	+0.406	+2.807	.020	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

CHAMP1 survival (RNA) · tumor vs normal (RNA) · all CHAMP1 data types