CHAF1A

Across TCGA pan-cancer cohorts, CHAF1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHAF1A data layer compared with 31 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CHAF1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHAF1A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, OV, and LUAD are the cancer types where CHAF1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.888	0.489	.007	31	view →
OV	DFS	Median	All	0.623	1.000	.033	20	view →
LUAD	DFS	Tertile	II,III,IV	0.221	1.000	.002	16	view →
CCRCC	DFS	Tertile	III,IV	0.189	0.908	.006	14	view →
PDAC	DFS	Quartile	II,III,IV	0.280	0.695	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHAF1A–LSCC (DFS)

Open the LSCC breakdown →