CHAD

Across TCGA patient cohorts, CHAD protein abundance is significantly associated with the RNA expression of many other genes, with 7,417 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHAD-associated genes across cancer lineages are ZNF423, ECRG4, and CPXM2. Each is linked with CHAD in more than 2 cancer types. Because this analysis shows association rather than direction, both CHAD-to-partner and partner-to-CHAD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHAD versus ZNF423 in BRCA, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAD→partner) and Y-score (partner→CHAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF423 →	+0.625	+0.828	<.001	<.001	3	3
CCRCC	ECRG4 →	+1.081	+0.491	<.001	<.001	3	3
CCRCC	CPXM2 →	+1.271	+0.618	<.001	.001	3	3
BRCA	SYNE1 →	+0.657	+1.371	<.001	<.001	3	3
CCRCC	NEIL1 →	+0.914	+0.553	<.001	<.001	3	3
BRCA	GNA14 →	+1.524	+1.524	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,417 associations by consensus.

CHAD vs ZNF423 — BRCA

Explore this scatter interactively →