CHAD

Across TCGA patient cohorts, CHAD mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAD-associated genes across cancer lineages are SLC1A5, GAPDH, and Acetyl-a-Tubulin-Lys40. Each is linked with CHAD in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAD-to-partner and partner-to-CHAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC1A5 grouped by CHAD-low versus CHAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAD→partner) and Y-score (partner→CHAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC1A5 →	-0.606	-3.452	.004	.005	3	1
UCEC	GAPDH →	-0.533	-2.321	.048	.035	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	-0.527	-2.321	.039	.035	2	1
UCEC	Notch1 →	+0.168	+3.459	.017	.005	1	1
UCEC	Rad50 →	-0.280	-3.459	.021	.005	1	1
UCEC	S6_pS240_S244 →	+0.560	+2.321	.006	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC1A5 by CHAD expression — UCEC

Explore this box plot interactively →