CHAD

Across TCGA cell cohorts, CHAD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,776 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHAD-associated GO terms across cancer lineages are mRNA splice site recognition, Negative regulation of myoblast fusion, and Protein localization to cytoplasmic stress granule. Each is linked with CHAD in more than 14 cancer types. Because this analysis shows association rather than direction, both CHAD-to-partner and partner-to-CHAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by CHAD-low versus CHAD-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAD→partner) and Y-score (partner→CHAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.133	+0.516	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.132	+0.617	<.001	<.001	3	15
PANCREAS	Protein localization to cytoplasmic stress granule →	+0.113	+0.451	<.001	.008	3	14
URINARY_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.119	+0.964	<.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.125	+0.661	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.127	+0.527	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,776 associations by consensus.

mRNA splice site recognition by CHAD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →