CHAD

Across TCGA cell cohorts, CHAD mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHAD-associated genes across cancer lineages are SMIM23 and IQCF5. Each is linked with CHAD in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAD-to-partner and partner-to-CHAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by CHAD-low versus CHAD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAD→partner) and Y-score (partner→CHAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SMIM23 by CHAD expression — BLOOD_Leukemia

Explore this box plot interactively →