CHAC2

Across TCGA pan-cancer cohorts, CHAC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHAC2 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CHAC2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CHAC2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where CHAC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.609	.007	32	view →
PDAC	OS	Tertile	II,III,IV	0.358	0.670	.009	16	view →
HNSC	OS	Median	III,IV	0.775	0.548	.012	11	view →
CCRCC	OS	Quartile	III,IV	0.532	0.944	.036	5	view →
GBM	DFS	Tertile	All	0.661	0.790	.036	4	view →
UCEC	DFS	Median	All	0.942	1.000	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHAC2–LSCC (OS)

Open the LSCC breakdown →