CHAC2

Across TCGA patient cohorts, CHAC2 mutation is significantly associated with the RNA expression of many other genes, with 1,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAC2-associated genes across cancer lineages are MIR4262, MIR4445, and RNU6-966P. Each is linked with CHAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAC2-to-partner and partner-to-CHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4262 grouped by CHAC2-low versus CHAC2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAC2→partner) and Y-score (partner→CHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4262 →	+0.734	+7.731	<.001	.009	3	2
UCEC	MIR4445 →	+0.215	+4.777	<.001	.002	3	2
BLCA	RNU6-966P →	+0.723	+7.640	<.001	.009	3	2
UCEC	DOC2B →	-1.283	-3.584	<.001	.002	3	1
UCEC	MIR7702 →	+0.245	+4.360	<.001	.004	3	1
UCEC	MIR6864 →	+0.784	+2.324	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,089 associations by consensus.

MIR4262 by CHAC2 expression — BRCA

Explore this box plot interactively →