CHAC2

Across TCGA patient cohorts, CHAC2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAC2-associated genes across cancer lineages are Notch1, PCNA, and Caspase-8. Each is linked with CHAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAC2-to-partner and partner-to-CHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CHAC2-low versus CHAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAC2→partner) and Y-score (partner→CHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.212	+3.183	.003	.009	3	1
UCEC	PCNA →	+0.265	+3.000	.019	.036	2	1
UCEC	Caspase-8 →	-0.291	-3.321	.027	.010	2	1
UCEC	EGFR_pY1068 →	-0.321	-3.321	.014	.010	1	1
UCEC	eIF4E →	+0.233	+3.321	.035	.010	1	1
UCEC	JNK2 →	+0.265	+3.321	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by CHAC2 expression — UCEC

Explore this box plot interactively →