CHAC2

Across TCGA cell cohorts, CHAC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,356 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHAC2-associated GO terms across cancer lineages are Protein localization to kinetochore, DNA replication initiation, and Maturation of SSU-rRNA. Each is linked with CHAC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both CHAC2-to-partner and partner-to-CHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to kinetochore grouped by CHAC2-low versus CHAC2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAC2→partner) and Y-score (partner→CHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein localization to kinetochore →	+0.175	+1.157	<.001	<.001	3	18
PANCREAS	DNA replication initiation →	+0.206	+1.179	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.125	+1.576	.001	<.001	3	17
LUNG_NSCLC_LUSC	Methylation →	+0.075	+1.467	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication checkpoint signaling →	+0.171	+1.661	<.001	<.001	3	17
OESOPHAGUS	Nucleolar large rRNA transcription by RNA polymerase I →	+0.158	+1.792	.002	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,356 associations by consensus.

Protein localization to kinetochore by CHAC2 expression — PANCREAS

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