CHAC1

Across TCGA cell cohorts, CHAC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,324 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHAC1-associated GO terms across cancer lineages are Negative regulation of translation in response to endoplasmic reticulum stress, Glycine import across plasma membrane, and Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Each is linked with CHAC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both CHAC1-to-partner and partner-to-CHAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translation in response to endoplasmic reticulum stress grouped by CHAC1-low versus CHAC1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAC1→partner) and Y-score (partner→CHAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.211	+2.801	<.001	<.001	3	18
OVARY	Glycine import across plasma membrane →	+1.204	+1.620	<.001	<.001	3	15
BLOOD_Myeloma	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.121	+2.242	<.001	<.001	3	15
SKIN	L-alanine catabolic process →	+1.072	+1.865	<.001	<.001	3	15
BLOOD_Myeloma	PERK-mediated unfolded protein response →	+0.243	+2.608	<.001	<.001	3	14
OESOPHAGUS	Transsulfuration →	+0.281	+2.772	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,324 associations by consensus.

Negative regulation of translation in response to endoplasmic reticulum stress by CHAC1 expression — BLOOD_Myeloma

Explore this box plot interactively →