CHAC1

Across TCGA cell cohorts, CHAC1 mutation is significantly associated with the mutation status of many other genes, with 1,161 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHAC1-associated genes across cancer lineages are PRUNE1, CHRM4, and LHFPL3. Each is linked with CHAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHAC1-to-partner and partner-to-CHAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRUNE1 grouped by CHAC1-low versus CHAC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAC1→partner) and Y-score (partner→CHAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRUNE1 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	CHRM4 →	+3.672	+5.083	.001	.001	1	2
BLOOD_Leukemia	LHFPL3 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	GNL1 →	+6.479	+6.479	<.001	<.001	1	2
BLOOD_Leukemia	COBLL1 →	+3.309	+4.794	.002	.002	1	2
BLOOD_Leukemia	MRPL2 →	+4.309	+4.560	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

PRUNE1 by CHAC1 expression — BLOOD_Leukemia

Explore this box plot interactively →