CGREF1

Across TCGA pan-cancer cohorts, CGREF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CGREF1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CGREF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CGREF1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where CGREF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.607	0.941	.009	28	view →
CCRCC	DFS	Median	All	0.851	0.982	.009	14	view →
GBM	OS	Tertile	All	0.547	0.279	.012	8	view →
LSCC	OS	Median	III,IV	0.664	0.996	.015	7	view →
PDAC	DFS	Tertile	All	0.305	0.525	.023	6	view →
HNSC	DFS	Median	II,III,IV	0.549	0.753	.013	6	view →
UCEC	DFS	Median	All	0.905	0.740	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CGREF1–LUAD (DFS)

Open the LUAD breakdown →