CGREF1

Across TCGA patient cohorts, CGREF1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGREF1-associated genes across cancer lineages are Notch1, Caspase-8, and C-Raf. Each is linked with CGREF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CGREF1-to-partner and partner-to-CGREF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CGREF1-low versus CGREF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGREF1→partner) and Y-score (partner→CGREF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+2.321	.018	.035	3	2
UCEC	Caspase-8 →	-0.258	-2.321	.041	.035	3	2
UCEC	C-Raf →	+0.217	+3.169	.002	.019	3	2
UCEC	EGFR_pY1068 →	-0.310	-3.459	.014	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.183	-2.308	.031	.036	3	1
UCEC	JNK2 →	+0.334	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by CGREF1 expression — UCEC

Explore this box plot interactively →