CGNL1

Across TCGA patient cohorts, CGNL1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGNL1-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and 4E-BP1. Each is linked with CGNL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CGNL1-to-partner and partner-to-CGNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CGNL1-low versus CGNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGNL1→partner) and Y-score (partner→CGNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.125	+2.920	.004	<.001	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.329	-1.340	.020	.015	3	3
UCEC	4E-BP1 →	+0.287	+2.906	<.001	.001	3	3
UCEC	FoxM1 →	+0.207	+1.836	.011	.001	3	2
UCEC	INPP4B →	-0.222	-2.087	.029	.004	3	2
UCEC	PDCD4 →	-0.551	-2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Notch1 by CGNL1 expression — UCEC

Explore this box plot interactively →