CGN

Across TCGA patient cohorts, CGN mutation is significantly associated with the RNA expression of many other genes, with 3,082 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGN-associated genes across cancer lineages are PPP6R2, SHMT2, and MFAP1. Each is linked with CGN in more than 3 cancer types. Because this analysis shows association rather than direction, both CGN-to-partner and partner-to-CGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP6R2 grouped by CGN-low versus CGN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGN→partner) and Y-score (partner→CGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP6R2 →	+0.352	+2.328	.007	.003	3	3
UCEC	SHMT2 →	+0.529	+2.523	<.001	<.001	3	3
UCEC	MFAP1 →	+0.570	+2.917	<.001	<.001	3	3
UCEC	BAG3 →	+0.582	+1.947	<.001	<.001	3	3
COAD	TYW3 →	+0.573	+3.210	.002	.009	3	3
COAD	LETM1 →	+0.524	+3.237	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,082 associations by consensus.

PPP6R2 by CGN expression — SKCM

Explore this box plot interactively →