CGN

Across TCGA patient cohorts, CGN mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGN-associated genes across cancer lineages are PCNA, Annexin-1, and ASNS. Each is linked with CGN in more than 2 cancer types. Because this analysis shows association rather than direction, both CGN-to-partner and partner-to-CGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CGN-low versus CGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGN→partner) and Y-score (partner→CGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.165	+1.222	.018	.035	3	3
UCEC	Annexin-1 →	+0.563	+2.434	<.001	.001	3	3
UCEC	ASNS →	+0.439	+1.502	<.001	.027	3	3
UCEC	ERK2 →	+0.188	+3.459	.002	.005	3	2
UCEC	MEK1 →	+0.374	+3.247	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.986	.019	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by CGN expression — UCEC

Explore this box plot interactively →