CGN

Across TCGA cell cohorts, CGN mutation is significantly associated with the RNA expression of many other genes, with 1,080 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CGN-associated genes across cancer lineages are KLF1, KLHL2, and SETD7. Each is linked with CGN in more than 2 cancer types. Because this analysis shows association rather than direction, both CGN-to-partner and partner-to-CGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF1 grouped by CGN-low versus CGN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGN→partner) and Y-score (partner→CGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLF1 →	+0.074	+2.584	.003	.005	3	2
LARGE_INTESTINE	KLHL2 →	+0.781	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	SETD7 →	+0.945	+3.321	<.001	.002	3	2
LARGE_INTESTINE	PAQR3 →	+0.826	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	PGRMC2 →	+0.535	+2.502	.004	.005	3	2
LARGE_INTESTINE	ZNF664 →	+0.399	+2.502	.009	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

KLF1 by CGN expression — LARGE_INTESTINE

Explore this box plot interactively →