CGAS

Across TCGA pan-cancer cohorts, CGAS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CGAS data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher CGAS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CGAS expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

GBM, LUAD, and LSCC are the cancer types where CGAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.233	0.464	.001	16	view →
LUAD	DFS	Quartile	III,IV	0.879	0.281	.026	8	view →
LSCC	DFS	Quartile	All	1.000	0.369	.004	6	view →
PDAC	OS	Quartile	III,IV	0.325	0.624	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CGAS–GBM (DFS)

Open the GBM breakdown →