CFP

Across TCGA patient cohorts, CFP mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFP-associated genes across cancer lineages are FoxM1, Ku80, and p62 Lck ligand. Each is linked with CFP in more than 1 cancer types. Because this analysis shows association rather than direction, both CFP-to-partner and partner-to-CFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CFP-low versus CFP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFP→partner) and Y-score (partner→CFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.210	+1.584	.015	.009	3	2
UCEC	Ku80 →	+0.242	+2.009	.002	.005	3	2
UCEC	p62 Lck ligand →	+0.255	+2.916	.019	<.001	3	2
UCEC	VHL →	-0.687	-1.321	.002	.029	3	2
UCEC	ATM →	-0.588	-2.986	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.364	-3.058	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FoxM1 by CFP expression — UCEC

Explore this box plot interactively →