CFLAR

Across TCGA patient cohorts, CFLAR protein abundance is significantly associated with the RNA expression of many other genes, with 14,638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CFLAR-associated genes across cancer lineages are TMEM241, CR1L, and MCF2L. Each is linked with CFLAR in more than 4 cancer types. Because this analysis shows association rather than direction, both CFLAR-to-partner and partner-to-CFLAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CFLAR versus TMEM241 in PDAC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFLAR→partner) and Y-score (partner→CFLAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM241 →	-0.592	-0.337	<.001	<.001	3	5
CCRCC	CR1L →	+0.591	+0.216	.001	.004	3	4
HNSC	MCF2L →	-0.902	-0.477	<.001	<.001	3	4
BRCA	RAC2 →	+0.798	+0.335	.006	.004	3	4
LSCC	TESPA1 →	+0.671	+0.307	<.001	<.001	3	4
LSCC	NT5C3B →	-0.613	-0.253	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,638 associations by consensus.

CFLAR vs TMEM241 — PDAC

Explore this scatter interactively →