CFLAR

Across TCGA patient cohorts, CFLAR mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFLAR-associated genes across cancer lineages are ERK2, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with CFLAR in more than 1 cancer types. Because this analysis shows association rather than direction, both CFLAR-to-partner and partner-to-CFLAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CFLAR-low versus CFLAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFLAR→partner) and Y-score (partner→CFLAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.133	+1.584	.026	.017	3	2
UCEC	4E-BP1_pT37_T46 →	-0.314	-1.401	.006	.040	3	2
UCEC	Caspase-7-cleavedD198 →	+0.521	+1.201	.004	.028	3	2
SKCM	eIF4E →	+0.200	+3.321	.030	.010	2	2
SKCM	SCD →	+0.237	+3.321	.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.091	-1.430	.018	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ERK2 by CFLAR expression — UCEC

Explore this box plot interactively →