Across TCGA pan-cancer cohorts, CFLAR-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CFLAR-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CFLAR-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CFLAR-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, ACC, and SKCM are the cancer types where CFLAR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.431	0.278	<.001	93	view →
ACC	OS	Tertile	All	0.295	0.828	.001	47	view →
SKCM	DFS	Tertile	All	0.658	0.499	.003	41	view →
LGG	DFS	Median	All	0.672	0.790	<.001	40	view →
UVM	DFS	Tertile	III,IV	0.299	0.744	.002	37	view →
BRCA	DFS	Median	III,IV	0.614	0.392	.002	35	view →
THCA	DFS	Tertile	II,III,IV	0.607	0.898	.001	34	view →
GBM	DFS	Median	All	0.194	0.312	.001	30	view →
OV	DFS	Median	II,III,IV	0.419	0.342	.009	28	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LUSC	DFS	Tertile	All	0.695	0.785	.011	11	view →
READ	DFS	Median	IV	0.391	0.827	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: CFLAR-AS1 tumor-vs-normal RNA expression · all CFLAR-AS1 data types