CFL2

Across TCGA pan-cancer cohorts, CFL2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CFL2 data layer compared with 21 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CFL2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CFL2 expression acts as an unfavorable survival marker.

UCS and UCEC are the cancer types where CFL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.185	0.686	.034	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CFL2–UCS (OS)

Open the UCS breakdown →