CFL2

Across TCGA patient cohorts, CFL2 mutation is significantly associated with the RNA expression of many other genes, with 2,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFL2-associated genes across cancer lineages are YTHDF3-AS1, ARF4P1, and POM121C. Each is linked with CFL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFL2-to-partner and partner-to-CFL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YTHDF3-AS1 grouped by CFL2-low versus CFL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL2→partner) and Y-score (partner→CFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YTHDF3-AS1 →	+0.443	+2.724	.008	.003	3	1
UCEC	ARF4P1 →	+0.383	+2.199	.002	.008	3	1
UCEC	POM121C →	+0.440	+3.024	<.001	<.001	3	1
UCEC	ZNHIT3 →	+0.498	+2.895	<.001	<.001	3	1
UCEC	CYFIP1 →	+0.658	+2.523	<.001	<.001	3	1
UCEC	TAF9 →	+0.659	+2.392	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,104 associations by consensus.

YTHDF3-AS1 by CFL2 expression — UCEC

Explore this box plot interactively →