CFL2

Across TCGA patient cohorts, CFL2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFL2-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and eIF4E. Each is linked with CFL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFL2-to-partner and partner-to-CFL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CFL2-low versus CFL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL2→partner) and Y-score (partner→CFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.366	+2.502	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.241	-2.000	.014	.010	3	1
UCEC	eIF4E →	+0.165	+2.000	.046	.010	3	1
UCEC	A-Raf_pS299 →	-0.094	-2.584	.044	.010	3	1
UCEC	Notch1 →	+0.160	+3.183	.003	.009	3	1
UCEC	p21 →	+0.158	+3.169	.036	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p62 Lck ligand by CFL2 expression — UCEC

Explore this box plot interactively →