CFL2

Across TCGA cell cohorts, CFL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,727 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CFL2-associated GO terms across cancer lineages are Actin filament severing, Positive regulation of supramolecular fiber organization, and Positive regulation of actin filament bundle assembly. Each is linked with CFL2 in more than 15 cancer types. Because this analysis shows association rather than direction, both CFL2-to-partner and partner-to-CFL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament severing grouped by CFL2-low versus CFL2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL2→partner) and Y-score (partner→CFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament severing →	+0.229	+1.225	<.001	<.001	3	16
STOMACH	Positive regulation of supramolecular fiber organization →	+0.089	+2.472	<.001	<.001	3	14
BONE	Positive regulation of actin filament bundle assembly →	+0.152	+1.099	<.001	<.001	3	14
BONE	Positive regulation of stress fiber assembly →	+0.136	+1.059	<.001	<.001	3	14
LUNG_SCLC	Actin filament fragmentation →	+0.161	+1.820	<.001	<.001	3	14
BONE	Regulation of mesenchymal stem cell proliferation →	+0.285	+1.682	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,727 associations by consensus.

Actin filament severing by CFL2 expression — BONE

Explore this box plot interactively →