CFL1

Across TCGA pan-cancer cohorts, CFL1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CFL1 data layer compared with 30 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher CFL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CFL1 expression acts as an unfavorable survival marker.

GBM, PDAC, and LUAD are the cancer types where CFL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.595	0.814	.005	16	view →
PDAC	DFS	Median	III,IV	0.203	0.514	.020	6	view →
LUAD	OS	Median	III,IV	0.458	0.750	.015	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CFL1–GBM (DFS)

Open the GBM breakdown →