CFL1

Across TCGA patient cohorts, CFL1 mutation is significantly associated with the RNA expression of many other genes, with 205 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFL1-associated genes across cancer lineages are RNU6-389P, MIR1237, and RNA5SP432. Each is linked with CFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFL1-to-partner and partner-to-CFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-389P grouped by CFL1-low versus CFL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL1→partner) and Y-score (partner→CFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-389P →	+0.606	+5.017	<.001	.009	3	2
UCEC	MIR1237 →	+0.192	+4.300	<.001	.005	3	2
CESC	RNA5SP432 →	+0.393	+5.539	<.001	.004	3	2
CESC	RPL9P13 →	+0.141	+5.010	<.001	.009	3	2
BLCA	RPS28P1 →	+0.332	+5.914	<.001	<.001	3	1
BLCA	SLC25A15P4 →	+0.591	+4.463	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 205 associations by consensus.

RNU6-389P by CFL1 expression — COAD

Explore this box plot interactively →