CFL1

Across TCGA patient cohorts, CFL1 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFL1-associated genes across cancer lineages are GMP, CD8+ naive T-cells, and pDC. Each is linked with CFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFL1-to-partner and partner-to-CFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by CFL1-low versus CFL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL1→partner) and Y-score (partner→CFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GMP →	+0.056	+3.264	.001	.046	3	2
UCEC	CD8+ naive T-cells →	+0.039	+3.016	.005	.019	3	1
UCEC	pDC →	+0.050	+2.180	.049	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GMP by CFL1 expression — LUSC

Explore this box plot interactively →