CFL1

Across TCGA cell cohorts, CFL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,362 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CFL1-associated GO terms across cancer lineages are Positive regulation of attachment of mitotic spindle microtubules to kinetochore, Mitotic spindle midzone assembly, and Regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with CFL1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CFL1-to-partner and partner-to-CFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of attachment of mitotic spindle microtubules to kinetochore grouped by CFL1-low versus CFL1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CFL1→partner) and Y-score (partner→CFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.207	+0.815	.002	.007	3	15
PANCREAS	Mitotic spindle midzone assembly →	+0.259	+0.866	<.001	<.001	3	14
PANCREAS	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.147	+0.670	<.001	<.001	3	14
PANCREAS	Mitotic spindle elongation →	+0.259	+0.866	<.001	<.001	3	14
LARGE_INTESTINE	Protein depolymerization →	+0.089	+0.781	<.001	<.001	3	14
URINARY_TRACT	Regulation of metaphase plate congression →	+0.099	+0.697	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,362 associations by consensus.

Positive regulation of attachment of mitotic spindle microtubules to kinetochore by CFL1 expression — URINARY_TRACT

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