Across TCGA patient cohorts, CFI mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFI-associated genes across cancer lineages are eEF2, GAPDH, and JNK2. Each is linked with CFI in more than 1 cancer types. Because this analysis shows association rather than direction, both CFI-to-partner and partner-to-CFI results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFI→partner) and Y-score (partner→CFI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.405	+2.000	.003	.010	3	2
UCEC	GAPDH →	+0.679	+3.584	.001	.002	3	2
UCEC	JNK2 →	+0.244	+1.584	.001	.036	3	2
UCEC	Akt →	-0.209	-2.574	.019	.010	3	2
UCEC	p70-S6K_pT389 →	-0.167	-2.000	.025	.029	3	2
UCEC	PREX1 →	-0.323	-2.584	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

CFI survival (RNA) · tumor vs normal (RNA) · all CFI data types