CFHR5

Across TCGA pan-cancer cohorts, CFHR5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CFHR5 data layer compared with 16 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CFHR5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CFHR5 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where CFHR5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.768	0.946	.004	24	view →
PDAC	OS	Tertile	II,III,IV	0.689	1.000	.001	23	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	21	view →
LUAD	OS	Median	III,IV	0.321	0.823	.001	15	view →
LSCC	DFS	Quartile	II,III,IV	0.768	1.000	.006	14	view →
GBM	OS	Tertile	All	0.591	0.230	.008	9	view →
COAD	DFS	Tertile	All	0.868	1.000	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CFHR5–UCEC (DFS)

Open the UCEC breakdown →